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Multicenter Studies of Brain Morphometry

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Brain Morphometry

Part of the book series: Neuromethods ((NM,volume 136))

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Abstract

Methods enabling the characterization of brain morphometry have evolved exponentially in the last decades and have been shown important clinical applications. First MRI studies usually included a low number of subjects, but later on, it has become recognized that efforts from different research centers can be pooled by combining data acquisition and analyses toward large-scale collaborative projects. Large-scale studies have a number of advantages, with the most intuitive being the increase in the number of enrolled subjects and, consequently, statistical power. However, there are also a number of caveats including (but not limited to) the high cost in terms of human and economic resources and the intrinsic variation of acquired data linked to the different MRI technologies.

This chapter depicts the different categories of large-scale studies, according to the level of control and planning on data acquisition and analyses. It also describes the most relevant multicenter studies, from the first precursor consortia in the early 1990s to the most recent worldwide multimodal collaborative efforts.

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Notes

  1. 1.

    http://fcon_1000.projects.nitrc.org/indi/CoRR/html/index.html.

  2. 2.

    One Mind for Research. In http://www.onemind.org/Our-Solutions/Gemini.

  3. 3.

    http://enigma.ini.usc.edu/.

  4. 4.

    https://surfer.nmr.mgh.harvard.edu/.

  5. 5.

    https://cran.r-project.org/.

  6. 6.

    http://www.humanconnectome.org/data/.

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Author information

Authors and Affiliations

  1. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy

    Fabrizio Piras, Mariangela Iorio, Daniela Vecchio, Tommaso Gili, Federica Piras & Gianfranco Spalletta

  2. Centro Fermi—Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Rome, Italy

    Fabrizio Piras

  3. Department of Psychology, Sapienza University of Rome, Rome, Italy

    Daniela Vecchio

  4. IMT School for Advanced Studies—Lucca, Lucca, Italy

    Tommaso Gili

  5. Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA

    Gianfranco Spalletta

Authors
  1. Fabrizio Piras
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  2. Mariangela Iorio
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  3. Daniela Vecchio
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  4. Tommaso Gili
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  5. Federica Piras
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  6. Gianfranco Spalletta
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Corresponding author

Correspondence to Fabrizio Piras .

Editor information

Editors and Affiliations

  1. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy

    Gianfranco Spalletta

  2. Division of Neuropsychiatry Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA

    Fabrizio Piras

  3. IMT School for Advanced Studies–Lucca, Lucca, Italy

    Tommaso Gili

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Piras, F., Iorio, M., Vecchio, D., Gili, T., Piras, F., Spalletta, G. (2018). Multicenter Studies of Brain Morphometry. In: Spalletta, G., Piras, F., Gili, T. (eds) Brain Morphometry. Neuromethods, vol 136. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7647-8_13

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  • DOI: https://doi.org/10.1007/978-1-4939-7647-8_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7645-4

  • Online ISBN: 978-1-4939-7647-8

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