Abstract
Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.
Key words
- Low-protein rat
- Metabolic programming
- Insulin resistance
- Diabetes
- Psychiatric disorders
- Biomarkers
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Ma, D., Ozanne, S.E., Guest, P.C. (2018). Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_10
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DOI: https://doi.org/10.1007/978-1-4939-7614-0_10
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