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Susceptibility Weighted MRI in Rodents at 9.4 T

Part of the Methods in Molecular Biology book series (MIMB,volume 1718)

Abstract

Susceptibility Weighted Imaging (SWI) is an established part of the clinical neuroimaging toolbox and, since its inception, has also successfully been used in various preclinical studies. Exploiting the effect of variations of magnetic susceptibility between different tissues on the externally applied, static, homogeneous magnetic field, the method visualizes venous vasculature, hemorrhages and blood degradation products, calcifications, and tissue iron deposits. The chapter describes in vivo and ex vivo protocols for preclinical SWI in rodents.

Key words

  • SWI
  • Preclinical
  • MRI
  • Phase imaging
  • Magnetic susceptibility
  • Rodents
  • Mice
  • Rat
  • Gradient echo
  • Bold

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Acknowledgements

We are grateful to Drs. David Poulsen (Department of Neurosurgery, University at Buffalo) and Claire Modica (Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo) for support with the ex vivo experiments. Research reported in this publication was funded by the National Center for Advancing Translational Sciences of the National Institutes of Health under award Number UL1TR001412. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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Schweser, F., Preda, M., Zivadinov, R. (2018). Susceptibility Weighted MRI in Rodents at 9.4 T. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_13

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