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Intracerebral Hemorrhage in Mice

  • Damon Klebe
  • Loretta Iniaghe
  • Sherrefa Burchell
  • Cesar Reis
  • Onat Akyol
  • Jiping Tang
  • John H. ZhangEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1717)

Abstract

Intracerebral hemorrhage is the most devastating stroke subtype with high rates of mortality and morbidity. Furthermore, no clinically approved treatment exists that effectively increases survival or improves quality of life for survivors. Effective modeling is necessary to elucidate the pathophysiological mechanisms of intracerebral hemorrhage and evaluate potential therapeutic approaches. Rodent models are most utilized because of their cost-effectiveness, and because rodent brain development and structures are well documented. Herein, we describe two intracerebral hemorrhage mouse models: the autologous blood double-injection and collagenase infusion models.

Key words

Autologous blood Collagenase Intracerebral hemorrhage Stroke Mouse Animal model 

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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Damon Klebe
    • 1
  • Loretta Iniaghe
    • 1
  • Sherrefa Burchell
    • 1
  • Cesar Reis
    • 1
  • Onat Akyol
    • 1
  • Jiping Tang
    • 1
  • John H. Zhang
    • 1
    Email author
  1. 1.Department of Physiology & PharmacologyLoma Linda UniversityLoma LindaUSA

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