Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation

  • Travis M. Doggett
  • Jared J. Tur
  • Natascha G. Alves
  • Sarah Y. Yuan
  • Srinivas M. Tipparaju
  • Jerome W. BreslinEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1717)


Hypotension, cardiac depression, and elevated microvascular permeability are known problems that complicate resuscitation of patients following traumatic injury, particularly those who are also intoxicated from alcohol consumption. A conscious rat model of combined alcohol intoxication and hemorrhagic shock has been used to study the hemodynamic mechanisms involved. Here, we describe using this model to study microvascular leakage and cardiac electrical activity.

Key words

Hemorrhage Shock Alcohol Microcirculation Microvascular permeability Electrocardiogram 


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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Travis M. Doggett
    • 1
  • Jared J. Tur
    • 2
  • Natascha G. Alves
    • 1
  • Sarah Y. Yuan
    • 1
  • Srinivas M. Tipparaju
    • 1
    • 2
  • Jerome W. Breslin
    • 1
    Email author
  1. 1.Department of Molecular Pharmacology and Physiology, Morsani College of MedicineUniversity of South FloridaTampaUSA
  2. 2.Department of Pharmaceutical Sciences, College of PharmacyUniversity of South FloridaTampaUSA

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