MicroRNA, Noise, and Gene Expression Regulation
Gene regulatory network that determines the cellular functions exhibits stochastic fluctuations, or “noise,” in different layers. Noise has begun to be appreciated for many previously unrecognized functions in important cellular activities. In fact, molecular noise is unavoidable in both microbial and eukaryotic cells, the feedback system is established evolutionally to reduce noise or optimize the noise for cellular homeostasis. The small noncoding RNAs, particularly, microNRAs, post-transcriptionally and negatively regulate gene expressions. MicroRNAs function as a novel layer to buffer noise level, and stabilize mRNA and protein level to maintain normal cellular function. Furthermore, the changing of microRNA expression levels may increase the stochastic fluctuation leading to abnormal cellular function, even diseases.
Key wordsMicroRNAs Noise Gene regulatory network Stochastic fluctuation
- 13.Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT et al (2007) Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci U S A 104:16170–16175CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Wang X, Li Y, Xu X, Wang YH (2010) Toward a system-level understanding of microRNA pathway via mathematical modeling. Biosystems 100:31–38Google Scholar
- 24.Iorio MV, Piovan C, Croce CM (1799) Interplay between microRNAs and the epigenetic machinery: an intricate network. Biochim Biophys Acta 2010:694–701Google Scholar