Abstract
It is thought that the major factor responsible for cell damage is reactive oxygen species (ROS), but our recent studies have shown that acrolein (CH2=CH-CHO) produced from spermine and spermidine is more toxic than ROS. Thus, (1) the mechanism of acrolein production during brain stroke, (2) one of the mechanisms of acrolein toxicity, and (3) the role of glutathione in acrolein detoxification are described in this chapter.
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Acknowledgments
We are grateful to Dr. A.J. Michael for critical reading of the manuscript prior to submission.
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Igarashi, K., Uemura, T., Kashiwagi, K. (2018). Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines. In: Alcázar, R., Tiburcio, A. (eds) Polyamines. Methods in Molecular Biology, vol 1694. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7398-9_38
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DOI: https://doi.org/10.1007/978-1-4939-7398-9_38
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