Estimating Allele Frequencies

Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1666)

Abstract

Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimators of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele frequencies. Factors that influence allele frequencies in populations are also explained.

Key words

Allele Genotype Phenotype Natural estimator Unrelated individuals Related individuals Relatives Families Pedigree Founder Nonfounder Population genetics Disease research Hardy–Weinberg equilibrium Maximum likelihood estimation Log-likelihood Expectation-maximization algorithm ABO blood group Natural selection Mutation Migration Genetic drift Nonrandom mating 

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Arthritis and Clinical Immunology Research ProgramOklahoma Medical Research FoundationOklahoma CityUSA

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