Model-Free Linkage Analysis of a Quantitative Trait

  • Nathan J. Morris
  • Catherine M. Stein
Part of the Methods in Molecular Biology book series (MIMB, volume 1666)


Model-free methods of linkage analysis for quantitative traits are a class of easily implemented, computationally efficient and statistically robust approaches to searching for linkage to a quantitative trait. By “model-free” we refer to methods of linkage analysis that do not fully specify a genetic model (i.e., the causal allele frequency, and penetrance functions). In this chapter we briefly survey the methods that are available, and then we discuss the necessary steps to implement an analysis using the programs GENIBD, SIBPAL and RELPAL in the S.A.G.E. (Statistical Analysis for Genetic Epidemiology) software suite.


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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of Population and Quantitative Health SciencesCase Western Reserve UniversityClevelandUSA

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