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Biochemical Approaches for Glutamatergic Neurotransmission pp 51–82Cite as

Positron Emission Tomography of Metabotropic Glutamate Receptors

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Part of the book series: Neuromethods ((NM,volume 130))

Abstract

Positron emission tomography (PET) is a noninvasive molecular imaging technique which shows continually growing applications in both preclinical and clinical research besides its well established use in routine clinical practice. PET is a highly multidisciplinary technique requiring specialized knowledge and skills from teams of Chemists, Physicists, and Biologists/Medical staff. In this chapter, we discuss PET methodology through explanation of the general principles governing PET, the requirements for successful PET imaging and finally examples of application of PET in studying metabotropic glutamate receptors (mGlu). Unlike, groups II and III, group I of mGlu receptors has been extensively studied for which reason herein, mGlu5 and mGlu1 will be the focus of this chapter.

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Authors and Affiliations

  1. Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Robinson Way, Cambridge, CB2 0SZ, UK

    Selena Milicevic Sephton

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  1. Selena Milicevic Sephton
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Correspondence to Selena Milicevic Sephton .

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Editors and Affiliations

  1. Lyon Neuroscience Research Center, University Lyon 1, Lyon, France

    Sandrine Parrot

  2. Lyon Neuroscience Research Center, University Lyon 1, Lyon, France

    Luc Denoroy

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Sephton, S.M. (2018). Positron Emission Tomography of Metabotropic Glutamate Receptors. In: Parrot, S., Denoroy, L. (eds) Biochemical Approaches for Glutamatergic Neurotransmission. Neuromethods, vol 130. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7228-9_3

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  • DOI: https://doi.org/10.1007/978-1-4939-7228-9_3

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