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Involvement of MicroRNAs in Diabetes and Its Complications

  • Bin WuEmail author
  • Daniel Miller
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1617)

Abstract

Diabetes is a severe condition worldwide. It is characterized by chronic hyperglycemia and is caused by defects in insulin production, secretion, and action. Both genetic and environmental factors contribute to the development of type 1 and type 2 diabetes. The pathogenesis of diabetes is complex and the underlying molecular mechanisms are only partially understood. MicroRNAs (miRNAs) play a fundamental role in diabetes and its complications. This chapter focuses on the dysregulation of miRNAs involved in the regulation of pancreatic islet insulin production and secretion as well as action and signaling in peripheral tissues. The roles of miRNAs in the development of diabetic complications are also discussed. Modulating miRNA expression, by either upregulation or inhibition, holds a promise as a strategy for treating this metabolic disease.

Key words

MicroRNA Diabetes Insulin Insulin resistance Glucose homeostasis Diabetic complications 

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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of EndocrinologyFirst Affiliated Hospital, Kunming Medical UniversityKunmingChina
  2. 2.School of ComputingUniversity of South AlabamaMobileUSA

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