ArrayTrack: An FDA and Public Genomic Tool

  • Hong Fang
  • Stephen C. Harris
  • Zhenjiang Su
  • Minjun Chen
  • Feng Qian
  • Leming Shi
  • Roger Perkins
  • Weida TongEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1613)


A robust bioinformatics capability is widely acknowledged as central to realizing the promises of toxicogenomics. Successful application of toxicogenomic approaches, such as DNA microarrays, inextricably relies on appropriate data management, the ability to extract knowledge from massive amounts of data and the availability of functional information for data interpretation. At the FDA’s National Center for Toxicological Research (NCTR), we are developing a public microarray data management and analysis software, called ArrayTrack that is also used in the routine review of genomic data submitted to the FDA. ArrayTrack stores a full range of information related to DNA microarrays and clinical and nonclinical studies as well as the digested data derived from proteomics and metabonomics experiments. In addition, ArrayTrack provides a rich collection of functional information about genes, proteins, and pathways drawn from various public biological databases for facilitating data interpretation. Many data analysis and visualization tools are available with ArrayTrack for individual platform data analysis, multiple omics data integration and integrated analysis of omics data with study data. Importantly, gene expression data, functional information, and analysis methods are fully integrated so that the data analysis and interpretation process is simplified and enhanced. Using ArrayTrack, users can select an analysis method from the ArrayTrack tool box, apply the method to selected microarray data and the analysis results can be directly linked to individual gene, pathway, and Gene Ontology analysis. ArrayTrack is publicly available online (, and the prospective user can also request a local installation version by contacting the authors.

Key words

ArrayTrack Bioinformatics MAQC Pharmacogenomics VXDS VGDS Microarray Toxicogenomics Systems Toxicology Database Genomics 



Clinical Data Interchange Standard Consortium


Differentially Expressed Gene


Food and Drug Administration


Gene Ontology


Gene Ontology For Functional Analysis


Hierarchical Cluster Analysis


Ingenuity Pathway Analysis


Kyoto Encyclopedia of Genes and Genomes


MicroArray Quality Control


Minimum Information About a Microarray Experiment


National Center for Toxicological Research


Principal Component Analysis




Study Data Tabulation Model




Voluntary Genomic Data Submission


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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Hong Fang
    • 1
  • Stephen C. Harris
    • 2
  • Zhenjiang Su
    • 2
  • Minjun Chen
    • 2
  • Feng Qian
    • 1
  • Leming Shi
    • 2
  • Roger Perkins
    • 1
  • Weida Tong
    • 2
    Email author
  1. 1.Z-Tech Corporation, An ICF International CompanyJeffersonUSA
  2. 2.Division of Systems ToxicologyNational Center for Toxicological Research (NCTR), FDAJeffersonUSA

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