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Future Approaches to DNA Vaccination Against Hemorrhagic Fever Viruses

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Hemorrhagic Fever Viruses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1604))

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Abstract

To date, there is no protective vaccine for Ebola virus infection. Safety concerns have prevented the use of live-attenuated vaccines, and forced researchers to examine new vaccine formulations. DNA vaccination is an attractive method for inducing protective immunity to a variety of pathogens, but the low immunogenicity seen in larger animals and humans has hindered its usage. Various approaches have been used to improve the immunogenicity of DNA vaccines, but the most successful, and widespread, is electroporation. Of increasing interest is the use of molecular adjuvants to produce immunomodulatory signals that can both amplify and direct the immune response. When combined, these approaches have the possibility to push DNA vaccination into the forefront of medicine.

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Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army.

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Authors and Affiliations

  1. Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter St, Fort Detrick, MD, 21702, USA

    John J. Suschak & Connie S. Schmaljohn

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  1. John J. Suschak
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  2. Connie S. Schmaljohn
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Correspondence to John J. Suschak or Connie S. Schmaljohn .

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  1. School of Medicine, University of Maryland, Baltimore, Maryland, USA

    Maria S. Salvato

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Suschak, J.J., Schmaljohn, C.S. (2018). Future Approaches to DNA Vaccination Against Hemorrhagic Fever Viruses. In: Salvato, M. (eds) Hemorrhagic Fever Viruses. Methods in Molecular Biology, vol 1604. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6981-4_26

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  • DOI: https://doi.org/10.1007/978-1-4939-6981-4_26

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6980-7

  • Online ISBN: 978-1-4939-6981-4

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