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Synthetic Antibodies pp 341–352Cite as

Preparation of Molecularly Imprinted Microspheres by Precipitation Polymerization

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1575))

Abstract

Molecularly imprinted polymers (MIPs) gained an expansively growing interest in the past few decades. After an initial, explorative period of preparing MIPs exclusively with bulk polymerization, new polymer synthesis routes have been adapted to overcome the drawbacks of the traditional method. Among these the most appealing is precipitation polymerization that results in nano- and microspheres with narrow size distribution and makes the production of MIPs more straightforward. Here, we describe a precipitation polymerization protocol for a common small molecule template, propranolol that is carried out in the conventional way, in dilute monomer solution. Moreover, a modified precipitation polymerization protocol from concentrated monomer solution is presented for a diclofenac imprinted polymer which makes the synthesis even more versatile and circumvents the disadvantages of the dilute solution conditions.

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Acknowledgment

The authors gratefully acknowledge the financial support of the Hungarian Scientific Fund (Grant K104724).

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, H-1111, Budapest, Hungary

    Tibor Renkecz & Viola Horvath

Authors
  1. Tibor Renkecz
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  2. Viola Horvath
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Corresponding author

Correspondence to Viola Horvath .

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Editors and Affiliations

  1. MorphoSys AG, Discovery Alliances & Technologies, Planegg, Germany

    Thomas Tiller

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Renkecz, T., Horvath, V. (2017). Preparation of Molecularly Imprinted Microspheres by Precipitation Polymerization. In: Tiller, T. (eds) Synthetic Antibodies. Methods in Molecular Biology, vol 1575. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6857-2_21

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  • DOI: https://doi.org/10.1007/978-1-4939-6857-2_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6855-8

  • Online ISBN: 978-1-4939-6857-2

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