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CD95 pp 153-171 | Cite as

Sketching of CD95 Oligomers by In Silico Investigations

  • Nicolas Levoin
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1557)

Abstract

This work aimed at building a 3D model of trimeric apo CD95. By combining different molecular modeling approaches and experimental information, we have been able to obtain a consensual organization of the complex. Our strategy permitted the construction of a plausible trimer, and to sketch the interface between protomers. The final model will guide further experimental investigations and understanding of CD95 structure and functions.

Key words

CD95 Fas Homooligomer Trimer Protein model Model building 

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Bioprojet-BiotechSaint GregoireFrance

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