SH2 Domains pp 77-81 | Cite as

SH2 Ligand Prediction–Guidance for In-Silico Screening

Part of the Methods in Molecular Biology book series (MIMB, volume 1555)


Systematic identification of binding partners for SH2 domains is important for understanding the biological function of the corresponding SH2 domain-containing proteins. Here, we describe two different web-accessible computer programs, SMALI and DomPep, for predicting binding ligands for SH2 domains. The former was developed using a Scoring Matrix method and the latter based on the Support Vector Machine model.

Key words

SH2 SH2-peptide interactions Ligand prediction SMALI DomPep 


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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of Biochemistry, Schulich School of Medicine and DentistryWestern UniversityLondonCanada
  2. 2.Children’s Health Research InstituteLondonCanada
  3. 3.Medical College of Qingdao UniversityQingdaoChina

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