Therapeutic Application of Adult Stem Cells in the Heart

  • Taylor A. Johnson
  • Dinender K. SinglaEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1553)


Cell therapies have been explored as a potential treatment avenue to treat heart diseases, such as myocardial infarction, doxorubicin-induced cardiomyopathy, and heart failure. Embryonic and adult stem cells (ASCs) have been examined in animal and clinical settings. Unlike embryonic and induced pluripotent stem cells, ASCs do not pose a threat to form teratomas, nor do they have immune system concerns, making them ideal for therapeutic use in humans. In this review, we will investigate different characteristics and sources of adult stem cells and progenitor cells, as well as determine their efficacy in cell transplantation in experimental and clinical trials. In addition, we will propose other research avenues that may promote further understanding and use of ASCs in therapeutic designs.

Key words

Adult stem cells Progenitor cells Cardiovascular diseases 



The authors would like to thank Abed Naser for his artistic contributions.


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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical SciencesUniversity of Central FloridaOrlandoUSA

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