Antibiotics pp 63-83 | Cite as

Structure Elucidation of Antibiotics by NMR Spectroscopy

Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1520)

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for the structure elucidation of antibiotics in solution. Over the past 30 years there have been numerous publications describing the use of NMR to characterize naturally derived or synthetic antibiotics. A large number of one-dimensional (1D) and two-dimensional (2D) NMR methods are available today and the list continues to expand. In this chapter, we will consider the key NMR experiments that provide useful information for compound structure elucidation.

Key words

NMR Structure elucidation Antibiotics Natural products Callyaerin A 

Notes

Acknowledgment

This work was supported by the German Federal Ministry of Education and Research (BMBF; Bundesministerium für Bildung und Forschung).

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Institute of Pharmaceutical Biology and BiotechnologyHeinrich-Heine-UniversityDuesseldorfGermany
  2. 2.Pharmacognosy Department, Faculty of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  3. 3.Helmholtz Centre for Infection ResearchBraunschweigGermany

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