The production of biologically active metabolites, e.g., antimicrobial compounds, is an essential step in the discovery and development process of medicinal drugs based on natural products. To get a hand on the compound of interest it first has to be biosynthesized by the corresponding producer, mostly a microorganism. In this chapter, a general workflow, which can easily be adapted to the lab, is described. Both fermentation on solid and in liquid medium is explained, and examples of hand on procedures are given.
- Growth media
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This work was supported by the German Federal Ministry of Education and Research (BMBF) through the German Centre for Infection Research (DZIF) initiative.
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Harms, H., König, G.M., Schäberle, T.F. (2017). Production of Antimicrobial Compounds by Fermentation. In: Sass, P. (eds) Antibiotics. Methods in Molecular Biology, vol 1520. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6634-9_3
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-6632-5
Online ISBN: 978-1-4939-6634-9
eBook Packages: Springer Protocols