Encapsulation of the HDACi Ex527 into Liposomes and Polymer-Based Particles

  • Dorle Hennig
  • Diana ImhofEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1510)


Incorporation of drugs into particles can improve their therapeutic effectiveness. Solubility, half-life time, targeting, and the release of the drug can be modified by the encapsulation into a particle. Histone deacetylase inhibitors have a great potential to be used as therapeutics for many different diseases. In this chapter, we describe the inclusion of the low molar mass HDACi Ex527 into polymer-based particles and liposomes.

Key words

Histone deacetylase inhibitor Ex527 PLGA Acetalated dextran Liposomes Cellular uptake 



The authors acknowledge financial support by the Thuringian Ministry of Education, Science and Culture (#B514-09051) within the ProExcellence initiative “NanoConSens.”


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Institute for Molecular Medicine, Cancer and Inflammation ResearchUniversity of Southern DenmarkOdense CDenmark
  2. 2.Pharmaceutical Chemistry I, Institute of PharmacyRheinische Friedrich Wilhelms UniversityBonnGermany

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