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Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases

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Human Fungal Pathogen Identification

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1508))

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Abstract

Invasive fungal diseases are major complications associated with the treatment of hematologic malignancies. The integration of host-derived biomarkers into clinical processes to predict the risk and progression of fungal disease is a promising approach in immunocompromised patients. Recent insights into human antifungal immunity have highlighted the remarkable influence of host genetics in modulating susceptibility to infection. In this chapter, we describe protocols to examine human genetic variation and to assess its functional consequences using the pattern recognition receptor PTX3 as an example.

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Acknowledgements

This work was supported by the European Society of Clinical Microbiology and Infectious Diseases (Research Grant 2012 to A.C.) and the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BPD/96176/2013 to C.C. and IF/00735/2014 to A.C.). Further support was provided by FCT, cofunded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), the Quadro de Referência Estratégico Nacional (QREN) through the Fundo Europeu de Desenvolvimento Regional (FEDER), and the Projeto Estratégico PEst-C/SAU/LA0026/2013.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal

    Cristina Cunha, Samuel M. Gonçalves & Agostinho Carvalho Ph.D.

  2. ICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Cristina Cunha, Samuel M. Gonçalves & Agostinho Carvalho Ph.D.

Authors
  1. Cristina Cunha
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  2. Samuel M. Gonçalves
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  3. Agostinho Carvalho Ph.D.
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Corresponding author

Correspondence to Agostinho Carvalho Ph.D. .

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Editors and Affiliations

  1. Children’s Cancer Research Institute (CCRI), St.Anna Kinderkrebsforschung, Vienna, Austria

    Thomas Lion

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Cunha, C., Gonçalves, S.M., Carvalho, A. (2017). Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases. In: Lion, T. (eds) Human Fungal Pathogen Identification. Methods in Molecular Biology, vol 1508. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6515-1_7

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  • DOI: https://doi.org/10.1007/978-1-4939-6515-1_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6513-7

  • Online ISBN: 978-1-4939-6515-1

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