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Serological Approaches

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Human Fungal Pathogen Identification

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1508))

Abstract

The diagnosis of invasive fungal diseases (IFD) based on clinical, radiological, and conventional microbiological findings is not reliable and is often delayed. Non-culture-based methods with higher sensitivity and specificity may reduce diagnostic time and result in decreased IFD morbidity and mortality. These methods are now increasingly used to manage patients at risk of IFD. Among available biomarkers, fungal antigens have been investigated as an aid to early diagnosis and are predominantly used as screening tests to prompt antifungal treatment mainly in patients with hematological malignancies. The revised version of the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) consensus definitions includes some of these biological markers (galactomannan, 1,3-beta-d-glucan, cryptococcus antigen).

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Author information

Authors and Affiliations

  1. Department of Internal Medicine—Hematology and Oncology, Masaryk University and University Hospital Brno, Jihlavska 20, Brno, 62500, Czech Republic

    Barbora Weinbergerova, Iva Kocmanova, Zdenek Racil & Jiri Mayer

  2. Department of Microbiology, University Hospital Brno, Brno, Czech Republic

    Iva Kocmanova

  3. CEITEC—Central European Institute of Technology, Masaryk University, Brno, Czech Republic

    Zdenek Racil & Jiri Mayer

Authors
  1. Barbora Weinbergerova
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  2. Iva Kocmanova
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  3. Zdenek Racil
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  4. Jiri Mayer
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Corresponding author

Correspondence to Barbora Weinbergerova .

Editor information

Editors and Affiliations

  1. Children’s Cancer Research Institute (CCRI), St.Anna Kinderkrebsforschung, Vienna, Austria

    Thomas Lion

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Weinbergerova, B., Kocmanova, I., Racil, Z., Mayer, J. (2017). Serological Approaches. In: Lion, T. (eds) Human Fungal Pathogen Identification. Methods in Molecular Biology, vol 1508. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6515-1_11

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  • DOI: https://doi.org/10.1007/978-1-4939-6515-1_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6513-7

  • Online ISBN: 978-1-4939-6515-1

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