Skip to main content

Menopausal Symptoms and the Kampo Medicine: Tokishakuyakusan, Kamishoyosan, and Keishibukuryogan

  • Protocol
  • First Online:
Herbal Medicines

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Women in the menopausal transition and the postmenopausal period are affected with variety of physical and psychological symptoms. In a recent series of studies, we investigated the effects of three major Kampo formulae (Tokishakuyakusan, Kamishoyosan, and Keishibukuryogan) on Japanese peri- and postmenopausal women, and reached the following conclusions: (1) Each of the three formulae alleviates sleep disturbances, with Kamishoyosan the most effective in improving difficulty in initiating sleep and nonrestorative sleep; (2) Keishibukuryogan lowered the systolic and diastolic blood pressures, the pulse rate, and the resting energy expenditure of women with hypertension or high-normal blood pressure; and (3) Tokishakuyakusan could be an effective treatment for the women with both headaches and depression.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brett KM, Keenan NL (2007) Complementary and alternative medicine use among midlife women for reasons including menopause in the United States: 2002. Menopause 14(2):300–307

    Article  PubMed  Google Scholar 

  2. van der Sluijs CP, Bensoussan A, Liyanage L, Shah S (2007) Women’s health during mid-life survey: the use of complementary and alternative medicine by symptomatic women transitioning through menopause in Sydney. Menopause 14(3):397–403

    Article  PubMed  Google Scholar 

  3. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288(3):321–333

    Article  CAS  PubMed  Google Scholar 

  4. Anderson G, Limacher M, Assaf A, Bassford T, Beresford S, Black H, Bonds D, Brunner R, Brzyski R, Caan B et al (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the women’s health initiative randomized controlled trial. JAMA 291(14):1701–1712

    Article  CAS  PubMed  Google Scholar 

  5. Yu F, Takahashi T, Moriya J, Kawaura K, Yamakawa J, Kusaka K, Itoh T, Morimoto S, Yamaguchi N, Kanda A (2006) Traditional Chinese medicine and Kampo: a review from the distant past for the future. J Int Med Res 34(3):231–239

    Article  CAS  PubMed  Google Scholar 

  6. Scheid V, Ward T, Cha W-S, Watanabe K, Liao X (2010) The treatment of menopausal symptoms by traditional East Asian medicines: review and perspectives. Maturitas 66(2):111–130

    Article  PubMed  Google Scholar 

  7. Terauchi M, Hiramitsu S, Akiyoshi M, Owa Y, Kato K, Obayashi S, Matsushima E, Kubota T (2011) Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. Arch Gynecol Obstet 284(4):913–921

    Article  PubMed  Google Scholar 

  8. Terauchi M, Akiyoshi M, Owa Y, Kato K, Obayashi S, Kubota T (2011) Effects of the Kampo medication keishibukuryogan on blood pressure in perimenopausal and postmenopausal women. Int J Gynecol Obstet 114(2):149–152

    Article  Google Scholar 

  9. Terauchi M, Hiramitsu S, Akiyoshi M, Owa Y, Kato K, Obayashi S, Matsushima E, Kubota T (2014) Effects of the kampo formula tokishakuyakusan on headaches and concomitant depression in middle-aged women. Evid-Based Complement Alternat Med 2014:593560

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ohayon MM (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6(2):97–111

    Article  PubMed  Google Scholar 

  11. Cappuccio FP, Taggart FM, Kandala N-B, Currie A, Peile E, Stranges S, Miller MA (2008) Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31(5):619–626

    PubMed  PubMed Central  Google Scholar 

  12. Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, Nieto FJ (2005) Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med 165(8):863–868

    Article  PubMed  Google Scholar 

  13. Gottlieb DJ, Redline S, Nieto FJ, Baldwin CM, Newman AB, Resnick HE, Punjabi NM (2006) Association of usual sleep duration with hypertension: the sleep heart health study. Sleep 29(8):1009–1014

    PubMed  Google Scholar 

  14. Hall MH, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB (2008) Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep 31(5):635–643

    PubMed  PubMed Central  Google Scholar 

  15. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR (2002) Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 59(2):131–136

    Article  PubMed  Google Scholar 

  16. Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG (2000) A prospective population-based study of menopausal symptoms. Obstet Gynecol 96(3):351–358

    CAS  PubMed  Google Scholar 

  17. Kravitz HM, Ganz PA, Bromberger J, Powell LH, Sutton-Tyrrell K, Meyer PM (2003) Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition. Menopause 10(1):19–28

    PubMed  Google Scholar 

  18. Health NIo: National Institutes of Health State-of-the-Science Conference statement: management of menopause-related symptoms. Ann Intern Med 2005, 142(12 Pt 1): 1003–1013

    Google Scholar 

  19. Ohayon MM (2006) Severe hot flashes are associated with chronic insomnia. Arch Intern Med 166(12):1262–1268

    Article  PubMed  Google Scholar 

  20. Ensrud KE, Stone KL, Blackwell TL, Sawaya GF, Tagliaferri M, Diem SJ, Grady D (2009) Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes. Menopause 16(2):286–292

    Article  PubMed  Google Scholar 

  21. Zervas IM, Lambrinoudaki I, Spyropoulou AC, Koundi KL, Voussoura E, Tzavara C, Verdeli H, Aravantinos L, Creatsa M, Paparrigopoulos T (2009) Additive effect of depressed mood and vasomotor symptoms on postmenopausal insomnia. Menopause 16(4):837–842

    Article  PubMed  Google Scholar 

  22. Joffe H, Soares CN, Thurston RC, White DP, Cohen LS, Hall JE (2009) Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms. Menopause 16(4):671–679

    Article  PubMed  PubMed Central  Google Scholar 

  23. Terauchi M, Obayashi S, Akiyoshi M, Kato K, Matsushima E, Kubota T (2010) Insomnia in Japanese peri- and postmenopausal women. Climacteric 13(5):479–486

    Article  CAS  PubMed  Google Scholar 

  24. Mizowaki M, Toriizuka K, Hanawa T (2001) Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice possible mediation of neurosteroid synthesis. Life Sci 69(18):2167–2177

    Article  CAS  PubMed  Google Scholar 

  25. Matsumoto K, Kohno S-I, Qjima K, Tezuka Y, Kadota S, Watanabe H (1998) Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice. Life Sci 62(23):2073–2082

    Article  CAS  PubMed  Google Scholar 

  26. Shinno H, Inami Y, Inagaki T, Nakamura Y, Horiguchi J (2008) Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. Prog Neuropsychopharmacol Biol Psychiatry 32(3):881–885

    Article  PubMed  Google Scholar 

  27. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng Z-J, Flegal K, O’Donnell C, Kittner S et al (2006) Heart disease and stroke statistics–2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113(6):e85–e151

    Article  PubMed  Google Scholar 

  28. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D (1995) Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988–1991. Hypertension 25(3):305–313

    Article  CAS  PubMed  Google Scholar 

  29. Goto H, Shimada Y, Akechi Y, Kohta K, Hattori M, Terasawa K (1996) Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Planta Med 62(5):436–439

    Article  CAS  PubMed  Google Scholar 

  30. Yoo MY, Lee BH, Choi YH, Lee JW, Seo JH, Oh K-S, Koo H-N, Seo HW, Yon GH, Kwon DY et al (2006) Vasorelaxant effect of the rootbark extract of Paeonia moutan on isolated rat thoracic aorta. Planta Med 72(14):1338–1341

    Article  CAS  PubMed  Google Scholar 

  31. Yanaga A, Goto H, Nakagawa T, Hikiami H, Shibahara N, Shimada Y (2006) Cinnmaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta. Biol Pharm Bull 29(12):2415–2418

    Article  CAS  PubMed  Google Scholar 

  32. Preuss HG, Echard B, Polansky MM, Anderson R (2006) Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr 25(2):144–150

    Article  CAS  PubMed  Google Scholar 

  33. Sekiya N, Goto H, Tazawa K, Oida S, Shimada Y, Terasawa K (2002) Keishi-bukuryo-gan preserves the endothelium dependent relaxation of thoracic aorta in cholesterol-fed rabbit by limiting superoxide generation. Phytother Res 16(6):524–528

    Article  CAS  PubMed  Google Scholar 

  34. Sekiya N, Tanaka N, Itoh T, Shimada Y, Goto H, Terasawa K (1999) Keishi-bukuryo-gan prevents the progression of atherosclerosis in cholesterol-fed rabbit. Phytother Res 13(3):192–196

    Article  CAS  PubMed  Google Scholar 

  35. Goto H, Shimada Y, Sekiya N, Yang Q, Kogure T, Mantani N, Hikiami H, Shibahara N, Terasawa K (2004) Effects of Keishi-bukuryo-gan on vascular function and hemorheological factors in spontaneously diabetic (WBN/kob) rats. Phytomedicine 11(2/3):188–195

    Article  CAS  PubMed  Google Scholar 

  36. Haug TT, Mykletun A, Dahl AA (2004) The association between anxiety, depression, and somatic symptoms in a large population: the HUNT-II study. Psychosom Med 66(6):845–851

    Article  PubMed  Google Scholar 

  37. Lieba-Samal D, Wöber C (2011) Sex hormones and primary headaches other than migraine. Curr Pain Headache Rep 15(5):407–414

    Article  PubMed  Google Scholar 

  38. MacGregor EA (2009) Migraine headache in perimenopausal and menopausal women. Curr Pain Headache Rep 13(5):399–403

    Article  PubMed  Google Scholar 

  39. Zwart JA, Dyb G, Hagen K, Ødegård KJ, Dahl AA, Bovim G, Stovner LJ (2003) Depression and anxiety disorders associated with headache frequency. The Nord-Trøndelag Health Study. Eur J Neurol 10(2):147–152

    Article  PubMed  Google Scholar 

  40. Brown JP, Gallicchio L, Flaws JA, Tracy JK (2009) Relations among menopausal symptoms, sleep disturbance and depressive symptoms in midlife. Maturitas 62(2):184–189

    Article  PubMed  PubMed Central  Google Scholar 

  41. Terauchi M, Hiramitsu S, Akiyoshi M, Owa Y, Kato K, Obayashi S, Matsushima E, Kubota T (2013) Associations among depression, anxiety and somatic symptoms in peri- and postmenopausal women. J Obstet Gynaecol Res 39(5):1007–1013

    Article  PubMed  Google Scholar 

  42. Neri I, Granella F, Nappi R, Manzoni GC, Facchinetti F, Genazzani AR (1993) Characteristics of headache at menopause: a clinico-epidemiologic study. Maturitas 17(1):31–37

    Article  CAS  PubMed  Google Scholar 

  43. Freeman EW, Sammel MD, Lin H, Gracia CR, Kapoor S (2008) Symptoms in the menopausal transition: hormone and behavioral correlates. Obstet Gynecol 111(1):127–136

    Article  CAS  PubMed  Google Scholar 

  44. Aegidius KL, Zwart JA, Hagen K, Schei B, Stovner LJ (2007) Hormone replacement therapy and headache prevalence in postmenopausal women. The Head-HUNT study. Eur J Neurol 14(1):73–78

    Article  CAS  PubMed  Google Scholar 

  45. Mueller L (2000) Predictability of exogenous hormone effect on subgroups of migraineurs. Headache 40(3):189–193

    Article  CAS  PubMed  Google Scholar 

  46. Peng C, Xie X, Wang L, Guo L, Hu T (2009) Pharmacodynamic action and mechanism of volatile oil from Rhizoma Ligustici Chuanxiong Hort. on treating headache. Phytomedicine 16(1):25–34

    Article  CAS  PubMed  Google Scholar 

  47. Wang YH, Liang S, Xu DS, Lin X, He CY, Feng Y, Hong YL (2011) Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol 63(2):261–266

    Article  CAS  PubMed  Google Scholar 

  48. Xu F, Peng D, Tao C, Yin D, Kou J, Zhu D, Yu B (2011) Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of traditional Chinese medicine, on depression model in mice and rats. Phytomedicine 18(13):1130–1136

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masakazu Terauchi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media New York

About this protocol

Cite this protocol

Terauchi, M., Kubota, T. (2016). Menopausal Symptoms and the Kampo Medicine: Tokishakuyakusan, Kamishoyosan, and Keishibukuryogan. In: Inui, A. (eds) Herbal Medicines. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-4002-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-4002-8_7

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-4000-4

  • Online ISBN: 978-1-4939-4002-8

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics