Odontopathy and Herbal Medicine

  • Kojiro Yamaguchi
  • Tsuyoshi SugiuraEmail author
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


This chapter highlights several refractory odontopathies, such as (1) stomatitis, (2) chronic pain [burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP)], (3) dryness of mouth, (4) taste abnormality, and (5) temporomandibular joint disorder, in which use of Kampo medicines, on the basis of Kampo theory, could exert the maximum effects on human body.
  1. 1.

    In stomatitis, heat may affect the head, chest, and middle abdominal region. Stomatitis is also related to the generation of reactive oxygen species. There are many antioxidants in the crude extracts of Kampo medicines. It is possible to control environmental factors (cold, heat, dampness, dryness) and vital energy, blood, and fluid of the organ systemically using Kampo medicines to treat stomatitis and eliminate local reactive oxygen species accumulation.

  2. 2.

    BMS, glossalgia, and AFP are multifactorial syndromes involving the interaction of biological and psychological factors. Local temperature decrease and edema often occur in chronic pain. These are local circulatory disturbances that can be resolved by improving the flow of blood and fluid. Tokishakuyakusan (TSS) and Kamishoyosan (KSS) are effective for enhancing peripheral circulation. Those medicines such as Saikokaryukotuboreito (SRB), Yokukansan (YKS), KSS, and Saibokutou (SBT) can reduce stress. The clinical efficacy of KM for BMS and AFP may depend on the regulation of the mesolimbic dopaminergic and descending glutamatergic pain modulation systems.

  3. 3.

    Heat- and cold-dryness stages exist in dry mouth. Byakkokaninjinto is useful for heat-dryness, whereas ninjinyoeito, bakumondoto, and hochuekkito (HET) have moisturizing effects in the cold-dryness stage.

  4. 4.

    Taste abnormality: Bitterness is an indicated Syoyobyo stage in the Kampo theory. Saiko-containing formulae are useful for this symptom. Intense sweetness is a sign indicative of digestive canal dampness and heat. Rikkunsito (RKT), Hangeshashinto, etc. are effective for this symptom. The intense astringency can be regarded as a pathological condition of Shoyobyo stage or glossalgia. It is effective to treat with Saiko-containing formulae. Taste loss is a sign of spleen and stomach deficiency. Hozai such as HET, Juzentaihoto, RKT et al. are effective for this symptom.

  5. 5.

    Temporomandibular joint disorder: It is usually treated with Shakuyakukanzoto or Kakkonto in the case with myotonia and/or muscle pain. KSS, TSS, and keishibukuryogan are used for blood circulation improvement. KSS, YKS, SRB, SBT, etc. are usually used in the case of psychogenesis.


Key words

Kampo therapy Stomatitis Chronic pain Taste abnormality Dry mouth Temporomandibular joint disorder 


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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Research Field in Dentistry, Medical and Dental Science Area, Research and Education AssemblyKagoshima University Graduate SchoolKagoshimaJapan

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