Inchinkoto and Jaundice

  • Junichi ShodaEmail author
  • Eiji Warabi
  • Kosuke Okada
  • Masahiro Yamamoto
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


Patients suffering from cholestasis and jaundice are frequently encountered in daily clinical practice. Cholestasis is a pathological condition characterized by impaired bile formation and secretion in livers. The accompanying oxidative stress may damage hepatocytes and thereby result in severe jaundice (hyperbilirubinemia), leading to liver fibrosis. Kampo formulation inchinkoto (IKCT) has been recognized as a “magic bullet” for the treatment of jaundice. Although the potent hepatoprotective and choleretic actions and main active ingredients of IKCT have long been known, the recent advances in research of bile formation and hepatic transporters have opened a road to the understanding of the action mechanism. In this chapter, the molecular mechanism of the clinically useful actions induced by ICKT is described in detail.

Key words

Jaundice Cholestasis Bilirubin Inchikoto Genipin Abcc2 (Mrp2) Nrf2 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Junichi Shoda
    • 1
    Email author
  • Eiji Warabi
    • 2
  • Kosuke Okada
    • 1
  • Masahiro Yamamoto
    • 3
  1. 1.Division of Medical Sciences, Institute of Clinical MedicineUniversity of TsukubaTsukuba, IbarakiJapan
  2. 2.Division of Biomedical Sciences, Faculty of MedicineUniversity of TsukubaTsukuba, IbarakiJapan
  3. 3.Kampo Scientific Strategies Division, Tsumura & Co.Tsumura Research LaboratoriesIbarakiJapan

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