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Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

The application of systems biology tools in analyzing heterogeneous data from multiple sources has become a necessity, especially in biomarker discovery. Such tools were developed with several approaches to address different types of research questions and hypotheses. In the field of neurotrauma and traumatic brain injury (TBI), three distinct approaches have been used so far as systems biology tools, namely functional group categorization, pathway analysis, and protein-protein interaction (PPI) networks. The databases allow for query of the system to identify candidate targets which can be further studied to elucidate potential downstream biomarkers indicative of disease progression, severity, and improvement. The various systems biology tools, databases, and strategies that can be implemented on available TBI data in neuroproteomic studies are discussed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Graduate School and University Center of CUNY, 365 Fifth Avenue, New York, NY, 10016, USA

    Zaynab Jaber M.S.

  2. Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon

    Patrick Aouad

  3. Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Mohamad Al Medawar

  4. Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Hisham Bahmad

  5. Faculty of Medicine, Beirut Arab University, Beirut, Lebanon

    Hisham Bahmad & Hussein Abou-Abbass

  6. Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Zaynab Jaber M.S., Hussein Abou-Abbass & Firas Kobeissy Ph.D.

  7. Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, University of Florida, 4000 SW 23rd St., Apt. 5-204, Gainesville, FL, 32608, USA

    Firas Kobeissy Ph.D.

  8. Banyan Biomarkers, Inc, Alachua, FL, USA

    Firas Kobeissy Ph.D.

Authors
  1. Zaynab Jaber M.S.
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  2. Patrick Aouad
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  3. Mohamad Al Medawar
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  4. Hisham Bahmad
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  5. Hussein Abou-Abbass
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  6. Firas Kobeissy Ph.D.
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Corresponding authors

Correspondence to Zaynab Jaber M.S. or Firas Kobeissy Ph.D. .

Editor information

Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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Jaber, Z., Aouad, P., Al Medawar, M., Bahmad, H., Abou-Abbass, H., Kobeissy, F. (2016). Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_9

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3814-8

  • Online ISBN: 978-1-4939-3816-2

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