Injury Models of the Central Nervous System pp 211-230 | Cite as
Midline (Central) Fluid Percussion Model of Traumatic Brain Injury
- 15 Citations
- 1 Mentions
- 3.4k Downloads
Abstract
Research models of traumatic brain injury (TBI) hold significant validity towards the human condition, with each model replicating a subset of clinical features and symptoms. After 30 years of characterization and implementation, fluid percussion injury (FPI) is firmly recognized as a clinically relevant model of TBI, encompassing concussion through severe injury. The midline variation of FPI may best represent mild and diffuse clinical brain injury, because of the acute behavioral deficits, the late onset of subtle behavioral morbidities, and the absence of gross histopathology. This chapter outlines the procedures for midline (diffuse) FPI in adult male rats and mice. With these procedures, it becomes possible to generate brain-injured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.
Key words
Traumatic brain injury (TBI) Concussion Diffuse Fluid percussion Trauma Rodent Rat Mouse Experimental model Righting reflex Fencing response Postoperative careReferences
- 1.Dixon CE, Lighthall JW, Anderson TE (1988) Physiologic, histopathologic, and cineradiographic characterization of a new fluid-percussion model of experimental brain injury in the rat. J Neurotrauma 5:91–104CrossRefPubMedGoogle Scholar
- 2.Thibault LE, Meaney DF, Anderson BJ, Marmarou A (1992) Biomechanical aspects of a fluid percussion model of brain injury. J Neurotrauma 9:311–322CrossRefPubMedGoogle Scholar
- 3.Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, Young HF, Hayes RL (1987) A fluid percussion model of experimental brain injury in the rat. J Neurosurg 67:110–119CrossRefPubMedGoogle Scholar
- 4.McIntosh TK, Noble L, Andrews B, Faden AI (1987) Traumatic brain injury in the rat: characterization of a midline fluid-percussion model. Cent Nerv Syst Trauma 4:119–134CrossRefPubMedGoogle Scholar
- 5.McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL (1989) Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28:233–244CrossRefPubMedGoogle Scholar
- 6.Carbonell WS, Maris DO, McCall T, Grady MS (1998) Adaptation of the fluid percussion injury model to the mouse. J Neurotrauma 15:217–229CrossRefPubMedGoogle Scholar
- 7.Rowe RK, Harrison JL, Thomas TC, Pauly JR, Adelson PD, and Lifshitz J (2013) Using anesthetics and analgeics in experimental traumatic brain injury. Lab Anim (NY) 42:286–291 doi: 10.2038/laban.257
- 8.Lifshitz J (2008) Fluid percussion injury. In: Chen J, Xu X-M, Xu Z, Zhang CJ (eds) Animal models of acute neurological injuries. The Humana Press Inc., Totowa, NJGoogle Scholar