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The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain trauma that uses a pneumatically or electromagnetically controlled piston to induce reproducible and well-controlled injury. The CCI model was originally used in ferrets and it has since been scaled for use in many other species. This chapter will describe the historical development of the CCI model, compare and contrast the pneumatic and electromagnetic models, and summarize key short- and long-term consequences of TBI that have been gleaned using this model. In accordance with the recent efforts to promote high-quality evidence through the reporting of common data elements (CDEs), relevant study details—that should be reported in CCI studies—will be noted.

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Acknowledgements

Support for this chapter comes from the following government funding sources: Department of Veterans Affairs grant RR&D B1127-I, NIH-NINDS grant R01-NS079061, and NIH-NINR grants 1F31NR014957 and T32NR009759. Additional support for this chapter comes from the following foundations and professional societies: The Pittsburgh Foundation, Sigma Theta Tau International Eta Chapter, the International Society for Nurses in Genetics, and the American Association of Neuroscience Nursing/Neuroscience Nursing Foundation. We would also like to acknowledge Mr. Michael D. Farmer for his time in generating the figures and Mrs. Marilyn K. Farmer for her continued editorial support.

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Authors and Affiliations

  1. Safar Center for Resuscitation Research, University of Pittsburgh, 201 Hill Building, 3434 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Nicole Osier & C. Edward Dixon Ph.D.

  2. School of Nursing, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Nicole Osier

  3. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15260, USA

    C. Edward Dixon Ph.D.

  4. V.A. Pittsburgh Healthcare System, Pittsburgh, PA, 15240, USA

    C. Edward Dixon Ph.D.

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  1. Nicole Osier
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  2. C. Edward Dixon Ph.D.
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Correspondence to C. Edward Dixon Ph.D. .

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Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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Osier, N., Dixon, C.E. (2016). The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_11

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_11

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