ER to Golgi-Dependent Protein Secretion: The Conventional Pathway

  • Corrado Viotti
Part of the Methods in Molecular Biology book series (MIMB, volume 1459)


Secretion is the cellular process present in every organism that delivers soluble proteins and cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the trafficking route that secretory proteins undertake when are transported from the endoplasmic reticulum (ER) to the Golgi apparatus (GA), and subsequently to the plasma membrane (PM) via secretory vesicles or secretory granules. This book chapter recalls the fundamental steps in cell biology research contributing to the elucidation of CPS; it describes the most prominent examples of conventionally secreted proteins in eukaryotic cells and the molecular mechanisms necessary to regulate each step of this process.

Key words

ER Ribosome SRP Translocon COPII COPI SNARE Golgi TGN Secretory vesicles Secretory granules Plasma membrane Regulated secretion 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institute of Biochemistry and Biology, Plant PhysiologyUniversity of PotsdamPotsdamGermany

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