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“Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs

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Book cover G Protein-Coupled Receptor Kinases

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

As the largest known family of cell surface receptors and the most common therapeutic drug targets, G protein-coupled receptors (GPCRs) are at the center of modern medicine. Multiple site phosphorylation of GPCRs by G protein-coupled receptor kinases (GRKs) plays an essential role in the regulation of various functions and signaling cascades of a receptor. Research in recent years has elucidated a common mechanism by which different ligand-bound GPCRs engage different GRKs, which in turn phosphorylate distinct sites or overlapping sets of sites on the receptor. These different patterns of phosphorylation (the “barcode”) result in distinct consequences in receptor function and signaling. Here, we review these recent findings and discuss the ramifications of this phenomenon in biology and medicine.

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Authors and Affiliations

  1. Department of Pharmacology and Chemical Biology, University of Pittsburgh, W1318 Thomas E. Starzl Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA, 15261, USA

    Kunhong Xiao M.D., Ph.D. & Hongda Liu

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  1. Kunhong Xiao M.D., Ph.D.
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  2. Hongda Liu
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Correspondence to Kunhong Xiao M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Pharmacology, Vanderbilt University , NASHVILLE, Tennessee, USA

    Vsevolod V. Gurevich

  2. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA

    Eugenia V. Gurevich

  3. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA

    John J.G. Tesmer

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Xiao, K., Liu, H. (2016). “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs. In: Gurevich, V., Gurevich, E., Tesmer, J. (eds) G Protein-Coupled Receptor Kinases. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3798-1_5

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  • DOI: https://doi.org/10.1007/978-1-4939-3798-1_5

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  • Online ISBN: 978-1-4939-3798-1

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