Abstract
The majority of medical advances have been made using animals. Studies using mouse models of chikungunya-induced disease have proven invaluable for dissecting the intricate nature of the immune response to this viral infection and identifying potential targets for the development of treatment strategies. Herein we describe the common mouse models used to research the pathobiology of chikungunya virus infection to date.
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References
Weaver SC, Lecuit M (2015) Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 372(13):1231–1239. doi:10.1056/NEJMra1406035
Lumsden WH (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. II. General description and epidemiology. Trans R Soc Trop Med Hyg 49(1):33–57
World Health Organization (2015) Chikungunya, Fact sheet N°327 http://www.who.int/mediacentre/factsheets/fs327/en/. Accessed 22 October 2015
Mavale M, Parashar D, Sudeep A, Gokhale M, Ghodke Y, Geevarghese G, Arankalle V, Mishra AC (2010) Venereal transmission of Chikungunya virus by Aedes aegypti mosquitoes (Diptera: Culicidae). Am J Trop Med Hyg 83(6):1242–1244. doi:10.4269/ajtmh.2010.09-0577
Ross RW (1956) The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic. J Hyg 54(2):177–191
Singharaj P, Simasathien P, Halstead SB (1966) Recovery of dengue and Chikungunya viruses from Thai haemorrhagic fever patients by passage in sucking mice. Bull World Health Organ 35(1):66
Wang E, Volkova E, Adams AP, Forrester N, Xiao SY, Frolov I, Weaver SC (2008) Chimeric alphavirus vaccine candidates for Chikungunya. Vaccine 26(39):5030–5039. doi:10.1016/j.vaccine.2008.07.054
Kumar M, Sudeep AB, Arankalle VA (2012) Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against Chikungunya virus. Vaccine 30(43):6142–6149. doi:10.1016/j.vaccine.2012.07.072
Mallilankaraman K, Shedlock DJ, Bao H, Kawalekar OU, Fagone P, Ramanathan AA, Ferraro B, Stabenow J, Vijayachari P, Sundaram SG, Muruganandam N, Sarangan G, Srikanth P, Khan AS, Lewis MG, Kim JJ, Sardesai NY, Muthumani K, Weiner DB (2011) A DNA vaccine against Chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLoS Negl Trop Dis 5(1), e928. doi:10.1371/journal.pntd.0000928
Parashar D, Paingankar MS, Kumar S, Gokhale MD, Sudeep AB, Shinde SB, Arankalle VA (2013) Administration of E2 and NS1 siRNAs inhibit Chikungunya virus replication in vitro and protects mice infected with the virus. PLoS Negl Trop Dis 7(9), e2405. doi:10.1371/journal.pntd.0002405
Dhanwani R, Khan M, Lomash V, Rao PV, Ly H, Parida M (2014) Characterization of Chikungunya virus induced host response in a mouse model of viral myositis. PLoS One 9(3), e92813. doi:10.1371/journal.pone.0092813
Ziegler SA, Lu L, da Rosa AP, Xiao SY, Tesh RB (2008) An animal model for studying the pathogenesis of Chikungunya virus infection. Am J Trop Med Hyg 79(1):133–139
Shimizu S (2004) Routes of administration. In: Hedrich H (ed) The laboratory mouse. Elsevier, Berlin, pp 527–542
Chen W, Foo SS, Taylor A, Lulla A, Merits A, Hueston L, Forwood MR, Walsh NC, Sims NA, Herrero LJ, Mahalingam S (2015) Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by Chikungunya virus infection. J Virol 89(1):581–593. doi:10.1128/JVI.02034-14
Pal P, Fox JM, Hawman DW, Huang YJ, Messaoudi I, Kreklywich C, Denton M, Legasse AW, Smith PP, Johnson S, Axthelm MK, Vanlandingham DL, Streblow DN, Higgs S, Morrison TE, Diamond MS (2014) Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes. J Virol 88(15):8213–8226. doi:10.1128/JVI.01032-14
Gardner J, Anraku I, Le TT, Larcher T, Major L, Roques P, Schroder WA, Higgs S, Suhrbier A (2010) Chikungunya virus arthritis in adult wild-type mice. J Virol 84(16):8021–8032. doi:10.1128/JVI.02603-09, JVI.02603-09 (pii)
Gargiulo S, Greco A, Gramanzini M, Esposito S, Affuso A, Brunetti A, Vesce G (2012) Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research. ILAR J 53(1):E55–E69. doi:10.1093/ilar.53.1.55
Powers AM, Logue CH (2007) Changing patterns of Chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol 88(Pt 9):2363–2377. doi:10.1099/vir.0.82858-0
Morrison TE, Oko L, Montgomery SA, Whitmore AC, Lotstein AR, Gunn BM, Elmore SA, Heise MT (2011) A mouse model of Chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence. Am J Pathol 178(1):32–40. doi:10.1016/j.ajpath.2010.11.018
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Herrero, L.J., Rudd, P.A., Liu, X., Wolf, S., Mahalingam, S. (2016). Mouse Models of Chikungunya Virus. In: Chu, J., Ang, S. (eds) Chikungunya Virus. Methods in Molecular Biology, vol 1426. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3618-2_19
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DOI: https://doi.org/10.1007/978-1-4939-3618-2_19
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