Abstract
Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.
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Acknowledgments
This work was supported by the National Institutes of Health grants DK080221 (C.S.W.), 1F30DK096718-01A1 (B.P.), T32 GM07347 (NIH/NIGMS) (B.P.), Merit Review Grants from the Office of Medical Research, Department of Veterans Affairs 1I01BX001426 (C.S.W.), and ACS-RSG 116552 (C.S.W.).
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Parang, B., Barrett, C.W., Williams, C.S. (2016). AOM/DSS Model of Colitis-Associated Cancer. In: Ivanov, A. (eds) Gastrointestinal Physiology and Diseases. Methods in Molecular Biology, vol 1422. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3603-8_26
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DOI: https://doi.org/10.1007/978-1-4939-3603-8_26
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