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The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer

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Gastrointestinal Physiology and Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1422))

Abstract

The Mongolian gerbil is an efficient, robust, and cost-effective rodent model that recapitulates many features of H. pylori-induced gastric inflammation and carcinogenesis in humans, allowing for targeted investigation of the bacterial determinants and environmental factors and, to a lesser degree, host constituents that govern H. pylori-mediated disease. This chapter discusses means through which the Mongolian gerbil model has been used to define mechanisms of H. pylori-inflammation and cancer as well as the current materials and methods for utilizing this model of microbially induced disease.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue MRB IV 1030C, Nashville, TN, 37232-0252, USA

    Jennifer M. Noto, Judith Romero-Gallo, M. Blanca Piazuelo & Richard M. Peek Jr.

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  1. Jennifer M. Noto
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  2. Judith Romero-Gallo
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  3. M. Blanca Piazuelo
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  4. Richard M. Peek Jr.
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Corresponding author

Correspondence to Richard M. Peek Jr. .

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  1. Dept of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU, Richmond, Virginia, USA

    Andrei I. Ivanov

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Noto, J.M., Romero-Gallo, J., Piazuelo, M.B., Peek, R.M. (2016). The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer. In: Ivanov, A. (eds) Gastrointestinal Physiology and Diseases. Methods in Molecular Biology, vol 1422. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3603-8_24

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  • DOI: https://doi.org/10.1007/978-1-4939-3603-8_24

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