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Systems Medicine pp 375–404Cite as

Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine

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Part of the Methods in Molecular Biology book series (MIMB,volume 1386)

Abstract

Systems medicine is the application of systems biology concepts, methods, and tools to medical research and practice. It aims to integrate data and knowledge from different disciplines into biomedical models and simulations for the understanding, prevention, cure, and management of complex diseases. Complex diseases arise from the interactions among disease-influencing factors across multiple levels of biological organization from the environment to molecules. To tackle the enormous challenges posed by complex diseases, we need a modeling and simulation framework capable of capturing and integrating information originating from multiple spatiotemporal and organizational scales. Multiscale modeling and simulation in systems medicine is an emerging methodology and discipline that has already demonstrated its potential in becoming this framework. The aim of this chapter is to present some of the main concepts, requirements, and challenges of multiscale modeling and simulation in systems medicine.

Key words

  • Systems medicine
  • Complex disease
  • Modeling and simulation
  • Multiscale modeling and simulation

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Acknowledgements

A.G. Hoekstra acknowledges partial funding by Russian Scientific Foundation, grant # 14-11-00826.

Author information

Authors and Affiliations

  1. Biomedical Sciences Research Institute, University of Ulster, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK

    Alexandru Mizeranschi & Werner Dubitzky

  2. Chemistry Department, Centre for Computational Science, University College London, 20 Gordon Street, WC1H 0AJ, London, UK

    Derek Groen

  3. Netherlands eScience Center, Science Park 140, 1098 XG, Amsterdam, The Netherlands

    Joris Borgdorff

  4. Computational Science Lab, Institute for Informatics, Faculty of Science, University of Amsterdam, Sciencepark 904, 1098 XH, Amsterdam, The Netherlands

    Alfons G. Hoekstra

  5. Advanced Computing Lab, ITMO University, 197101, 49 Kronverkskiy av., St. Petersburg, Russia

    Alfons G. Hoekstra

  6. Computer Science Department, University of Geneva, 7 route de Drize, 1227, Carouge, Switzerland

    Bastien Chopard

  7. School of Biomedical Sciences, University of Ulster, Coleraine campus, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK

    Werner Dubitzky

Authors
  1. Alexandru Mizeranschi
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  2. Derek Groen
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  3. Joris Borgdorff
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  4. Alfons G. Hoekstra
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  5. Bastien Chopard
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  6. Werner Dubitzky
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Corresponding author

Correspondence to Werner Dubitzky .

Editor information

Editors and Affiliations

  1. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz

  2. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

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Mizeranschi, A., Groen, D., Borgdorff, J., Hoekstra, A.G., Chopard, B., Dubitzky, W. (2016). Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine. In: Schmitz, U., Wolkenhauer, O. (eds) Systems Medicine. Methods in Molecular Biology, vol 1386. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3283-2_17

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  • DOI: https://doi.org/10.1007/978-1-4939-3283-2_17

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3282-5

  • Online ISBN: 978-1-4939-3283-2

  • eBook Packages: Springer Protocols

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