Abstract
Using T-pattern analysis, a procedure developed for detecting a particular kind of nonrandomly recurring hierarchical and multi-ordinal real-time sequential patterns (T-patterns), we have inquired whether such patterns of action potentials (spikes) can be extracted from extracellular activity sampled simultaneously from many neurons across the mitral cell layer of the olfactory bulb (OB). Spikes were sampled from urethane-anesthetized rats over a 6 h recording session, or a period lasting as long as permitted by the physiological condition of the animal. Breathing was recorded as markers of peak inhalation and exhalation. Complex t-patterns of up to ~20 elements were identified with functional connections often spanning the full extent of the array. A considerable proportion of these sequences were related to breathing. By comparing sequence detection in our real data with that in the same data when randomized (using either of two procedures, one preserving the interval structure of each spike train, and so the more conservative), we find that the incidence of sequences is very much greater in the real than in the random data. Further, in cases where recordings were terminated before completion of the full recording session, the difference between pattern detection in real data and that of randomized data strongly correlated with the physiological condition of the animal—in recordings leading to the preparation becoming physiologically unstable, the number of patterns detected in real data approached that in the randomized data. We conclude that such sequences are an important physiological property of the neural system studied, and suggest that they may form a basis for encoding sensory information.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Griffith JS, Horn G (1963) Functional coupling between cells in the visual cortex of the unrestrained cat. Nature 199:893–895
Engel AK, Roelfsema PR, Fries P, Brecht M, Singer W (1997) Binding and response selection in the temporal domain—a new paradigm for neurobiological research. Theory Biosci 116:241–266
Hebb DO (1949) The organisation of behaviour. Wiley, New York, NY
Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in dentate area of anesthetized rabbit following stimulation of Perforant path. J Physiol 232:331–356
Abeles M, Gerstein GL (1988) Detecting spatiotemporal firing patterns among simultaneously recorded single neurons. J Neurophysiol 60:909–924
Oram MW, Hatsopoulos NG, Richmond BJ, Donoghue JP (2001) Excess synchrony in motor cortical neurons provides redundant direction information with that from coarse temporal measures. J Neurophysiol 86:1700–1716
Baker S, Lemon RN (2000) Precise spatiotemporal repeating patterns in monkey primary and supplementary motor areas occur at chance level. J Neurophysiol 84:1770–1780
Magnusson MS (2000) Discovering hidden time patterns in behavior: T-patterns and their detection. Behav Res Methods Instrum Comput 32:93–110
Magnusson MS (2004) Repeated patterns in behavior and other biological phenomena. In: Kimbrough Oller D, Griebel U (eds) Evolution of communication systems: a comparative approach (Vienna series in theoretical biology). The MIT Press, Cambridge, MA
Magnusson MS, Burfield I, Loijens L, Grieco F, Jonsson GK, Spink A (2004) Theme: Powerful Tool for Detection and Analysis of Hidden Patterns in Behavior. Reference Manual, Version 5.0. Noldus Information Technology BV, Wageningen, The Netherlands.
Bolhuis JJ, MacPhail EM (2001) A critique of the neuroecology of learning & memory. Trends Cogn Sci 5:426–433
Kendrick KM, Levy F, Keverne EB (1992) Changes in the sensory processing of olfactory signals induced by birth in sheep. Science 256:883–886
Kendrick KM, Guevara-Guzman R, Zorrilla J, Hinton MR, Broad KD, Mimmack M, Ohkura S (1997) Formation of olfactory memories mediated by nitric oxide. Nature 388:670–674
Da Costa APC, Broad KD, Kendrick KM (1997) Olfactory memory and maternal behaviour-induced changes in c-fos and zif/268 mRNA expression in the sheep brain. Mol Brain Res 46:53–76
Mori K, Nagau H, Yoshihara Y (1999) The olfactory bulb: coding and processing of odor molecule information. Science 286:711–715
Johnson BA, Ho SL, Yihan JS, Yip S, Hingco EE, Leon M (2002) Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. J Comp Neurol 449:180–194
Spors H, Grinvald A (2002) Spatio-temporal dynamics of odor representations in the mammalian olfactory bulb. Neuron 34:301–315
Nicol AU, Segonds-Pichon A, Magnusson MS (2015) Complex spike patterns in olfactory bulb neuronal networks. J Neurosci Methods 239:11–17
Price JL, Powell TPS (1969) The morphology of the granule cells of the olfactory bulb. J Cell Sci 7:91–123
Horton PM, Nicol AU, Kendrick KM, Feng JF (2007) Spike sorting based upon machine learning algorithms (SOMA). J Neurosci Methods 160:52–68
Aungst JL, Heyward PM, Puche AC, Karnup SV, Hayar A, Szabo G, Shipley MT (2003) Centre-surround inhibition among olfactory bulb glomeruli. Nature 426:623–629
Schrader S, Grün S, Diesmann M, Gerstein GL (2008) Detecting synfire chain activity with massively parallel spike train recording. J Neurophysiol 100:2165–2176
Gerstein GL, Williams ER, Diesmann M, Grün S, Trengrove C (2012) Detecting synfire chains in parallel spike data. J Neurosci Methods 206:54–64
Ikegaya I, Aaron G, Cossart R, Aronov D, Lampl I, Ferster D, Yuste R (2004) Synfire chains and cortical songs: temporal modules of cortical activity. Science 304:559–564
Gerstein GL (2004) Searching for significance in spatio-temporal firing patterns. Acta Neurobiol Exp 64:203–207
Zador A (1998) Impact of synaptic unreliability on the information transmitted by spiking neurons. J Neurophysiol 79:1219–1229
Margrie TW, Schaefer AT (2002) Theta oscillation coupled spike latencies yield computational vigour in a mammalian sensory system. J Physiol 546:363–374
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media New York
About this protocol
Cite this protocol
Nicol, A.U., Segonds-Pichon, A., Magnusson, M.S. (2016). Complex Spike Patterns in Olfactory Bulb Neuronal Networks. In: Magnusson, M., Burgoon, J., Casarrubea, M. (eds) Discovering Hidden Temporal Patterns in Behavior and Interaction. Neuromethods, vol 111. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3249-8_17
Download citation
DOI: https://doi.org/10.1007/978-1-4939-3249-8_17
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-3248-1
Online ISBN: 978-1-4939-3249-8
eBook Packages: Springer Protocols