Abstract
The efficacy of a given drug resides mainly on its ability to specifically target disease mechanisms.
Natural products represent the leading source of bioactive molecules with a broad range of activities.
It is becoming increasingly clear that natural compounds exert their chemopreventive or antitumoral activities targeting simultaneously diverse cellular pathways. Here we describe the use of antibody array to assess the effects of natural compounds on the expression of multiple proteins and of their posttranslational modifications in cellular systems. This might turn to be a very flexible application for cancer chemoprevention studies.
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Pulito, C., Sacconi, A., Korita, E., Maidecchi, A., Strano, S. (2016). Antibody Array as a Tool for Screening of Natural Agents in Cancer Chemoprevention. In: Strano, S. (eds) Cancer Chemoprevention. Methods in Molecular Biology, vol 1379. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3191-0_17
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DOI: https://doi.org/10.1007/978-1-4939-3191-0_17
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-3190-3
Online ISBN: 978-1-4939-3191-0
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