Abstract
Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body’s immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred.
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Singh, H., Gupta, S., Gautam, A., Raghava, G.P.S. (2015). Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines. In: Houen, G. (eds) Peptide Antibodies. Methods in Molecular Biology, vol 1348. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2999-3_28
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DOI: https://doi.org/10.1007/978-1-4939-2999-3_28
Publisher Name: Humana Press, New York, NY
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