Perspectives and Pitfalls in Nucleic Acids Crystallography

  • Eric Westhof
Part of the Methods in Molecular Biology book series (MIMB, volume 1320)


X-ray crystallography offers precious and striking knowledge on biomolecular architectures. Although safeguards do exist to guarantee the accuracy of the structures deposited in databases, they are not always applied, leading to the spread of inaccurate data. The importance of validation reports in the publication process is emphasized.

Key words

Nucleic acids Crystallography Model quality RNA DNA B factors Validation 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Architecture et Réactivité de l’ARN, Institut de Biologie Moléculaire et CellulaireUPR 9002 CNRS/Université de StrasbourgStrasbourgFrance

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