STAT3 Decoy ODN Therapy for Cancer

Part of the Methods in Molecular Biology book series (MIMB, volume 1317)


As an oncogene, over-activated signal transducer and activator of transcription 3 (STAT3) has been detected in many tumors. STAT3 controls cell differentiation, proliferation, and survival, and is associated with angiogenesis and immune dysfunction during tumorigenesis. Double-stranded decoy oligodeoxynucleotide (ODN) targeting over-activated STAT3 in tumor cells have shown significant antitumor efficiency. Here, we describe the materials and methods involved in STAT3 decoy ODN therapy for cancer including both the antitumor effect directly and immunotherapy indirectly.

Key words

STAT3 Decoy ODN Gene therapy Cancer 



This work was supported by Natural Science Foundation of China (#30628014; #30571696, #81172789, #30972692) and National 973 Science Program by Ministry of Science and Technology of China (2004CB518807).


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Biology Department, Shandong Quality Inspection Center For Medical DevicesJinanChina
  2. 2.Institute of Immunopharmacology & Immunotherapy, School of Pharmaceutical Sciences, Shandong UniversityJinanChina

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