Abstract
The quartz crystal microbalance with dissipation monitoring (QCM-D) is a highly sensitive, noninvasive, and label-free sensing device. This device is capable of providing real-time monitoring of the properties of complex biological systems, such as cells, in response to environmental stimuli. The unique dissipation monitoring function of the QCM-D has been shown to be able to profile the inhibition of signaling pathways mediated by epidermal growth factor receptors. The QCM-D method has the potential to become an effective sensing platform for drug screening.
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Chen, J.Y., Garcia, M.P., Penn, L.S., Xi, J. (2015). Use of the Quartz Crystal Microbalance with Dissipation Monitoring for Pharmacological Evaluation of Cell Signaling Pathways Mediated by Epidermal Growth Factor Receptors. In: Fang, Y. (eds) Label-Free Biosensor Methods in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2617-6_14
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DOI: https://doi.org/10.1007/978-1-4939-2617-6_14
Publisher Name: Humana Press, New York, NY
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