Mammary Stem Cells: A Clinician’s View

  • José SchneiderEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1293)


Mammary stem cells were identified and isolated more than a decade ago and, although much remains to be learned, a lot has been revealed about their properties and behavior. Yet there is a gap between the newly acquired knowledge and its successful clinical application. This chapter presented a critical view from the perspective of a clinician.

Key words

Cancer stem cells Breast cancer Therapy 


  1. 1.
    Al Hajj M, Wicha MS, Benito-Hernández A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100:15178–15183CrossRefGoogle Scholar
  2. 2.
    Hu Y, Fu L (2012) Targeting cancer stem cells: a new therapy to cure cancer patients. Am J Cancer Res 2:340–356PubMedCentralPubMedGoogle Scholar
  3. 3.
    Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7:1028–1034PubMedCrossRefGoogle Scholar
  4. 4.
    Gillet JP, Schneider J, Bertholet V, De Longueville F, Remacle J, Efferth T (2006) Microarray expression profiling of ABC transporters in Human Breast Cancer. Cancer Genomics Proteomics 3:97–106Google Scholar
  5. 5.
    Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: mirage or reality? Nat Med 15:1010–1012PubMedCrossRefGoogle Scholar
  6. 6.
    Volm M (1998) Multidrug resistance and its reversal. Anticancer Res 18:2905–2917PubMedGoogle Scholar
  7. 7.
    Gainor JF, Shaw AT (2013) Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer. J Clin Oncol 31:3987–3996PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media LLC New York 2015

Authors and Affiliations

  1. 1.Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosAlcorcónSpain

Personalised recommendations