Thyroxine-Induced Metamorphosis in the Axolotl (Ambystoma mexicanum)
The axolotl (Ambystoma mexicanum) has remained an important model for regeneration and developmental biology for over a century. Although axolotls in captive-bred colonies usually exist in an aquatic form, they retain the ability to undergo metamorphosis following exposure to thyroid hormone. Here we present a robust method for inducing metamorphosis in adult axolotls that results in high survivability and produces terrestrial animals that can be maintained in long-term captivity.
Key wordsMetamorphosis Thyroxine T4 Thyroid hormone Axolotl Ambystoma Salamander Regeneration
This work was supported by the Office of the Vice President of Research at the University of Kentucky.
- 3.Rosenkilde P, Ussing AP (1996) What mechanisms control neoteny and regulate induced metamorphosis in urodeles? Int J Dev Biol 40:665–673Google Scholar
- 5.Shaffer HB, Voss SR (1996) Phylogenetic and mechanistic analysis of a developmentally integrated character complex: alternate life history modes in ambystomatid salamanders. Am Zool 36:24–35Google Scholar