Sustained Delivery of Retinoids to Prevent Photoreceptor Death
Delivery of hydrophobic compounds to photoreceptors within the retina presents unique challenges due to the anatomy and physiology of the eye. Derivatives of vitamin A (retinoids) are essential to the function and survival of photoreceptors and in the absence of an intrinsic mechanism to metabolize these compounds (visual cycle) leads to extensive loss of photoreceptors and visual function. In this chapter, we describe a method for the sustained delivery of retinoids to young mice that lack a functioning visual cycle to promote survival of photoreceptors.
Key wordsCone death Retina Photoreceptor Retinoid Sustained delivery Visual cycle
This work was supported by the National Institutes of Health Grants R01 EY04939 (R.K.C.) and CO6 RR015455 (Medical University of South Carolina); Foundation Fighting Blindness, Inc. (R.K.C.); an unrestricted grant (Department of Ophthalmology, Medical University of South Carolina) from Research to Prevent Blindness (RPB); RPB Senior Scientific Investigator Award (R.K.C.); and RPB Medical Student Research Fellowship (P.H.T.).