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Modeling Cancer Using Genetically Engineered Mice

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Book cover Mouse Models of Cancer

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1267))

Abstract

Genetically engineered mouse (GEM) models have proven to be a powerful tool to study tumorigenesis. The mouse is the preferred complex organism used in cancer studies due to the high number and versatility of genetic tools available for this species. GEM models can mimic point mutations, gene amplifications, short and large deletions, translocations, etc.; thus, most of the genetic aberrations found in human tumors can be modeled in GEM, making GEM models a very attractive system. Furthermore, recent developments in mouse genetics may facilitate the generation of GEM models with increased mutational complexity, therefore resembling human tumors better. Within this review, we will discuss the different possibilities of modeling tumorigenesis using GEM and the future developments within the field.

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Acknowledgments

We thank Drs. Dagmar Stoiber-Sakaguchi and Robert Eferl for critical reading of the manuscript.

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Authors and Affiliations

  1. Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Währinger Str. 13a, Vienna, 1090, Austria

    Patricia Stiedl, Beatrice Grabner, Katalin Zboray, Edith Bogner & Emilio Casanova

  2. Center of Physiology and Pharmacology, Comprehensive Cancer Center, Institute of Pharmacology, Medical University of Vienna, Währinger Str. 13a, Vienna, 1090, Austria

    Emilio Casanova

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  1. Patricia Stiedl
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  2. Beatrice Grabner
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  3. Katalin Zboray
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  4. Edith Bogner
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Correspondence to Emilio Casanova .

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Editors and Affiliations

  1. Medical University Vienna (MUV) Institute for Cancer Research, Vienna, Austria

    Robert Eferl

  2. Research (LBI-CR), Medical University Vienna (MUV), Center of Physiology and Pharmacology & Ludwig Boltzmann Institute for Cancer, Vienna, Austria

    Emilio Casanova

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Stiedl, P., Grabner, B., Zboray, K., Bogner, E., Casanova, E. (2015). Modeling Cancer Using Genetically Engineered Mice. In: Eferl, R., Casanova, E. (eds) Mouse Models of Cancer. Methods in Molecular Biology, vol 1267. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2297-0_1

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