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Remote Control of Neural Activity Using Chemical Genetics

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Book cover Neural Tracing Methods

Part of the book series: Neuromethods ((NM,volume 92))

Abstract

Understanding how the nervous system functions requires a methodological toolbox for the manipulation of neuronal circuits. Over the last decade, there has been an explosion in the availability of methods to map and manipulate genetically defined populations of neurons. The control of neural signaling via pharmacological receptor-ligand interactions, or chemical genetics, allows for the modulation of neural signaling at an intermediate time scale and provides a complimentary approach to other technologies such as optogenetics. Here, we review the variety of chemical genetic techniques that are currently available and discuss the considerations that must be undertaken when choosing a technique for a particular experimental system.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA

    Andrew J. Murray

  2. Institute of Physiology, Christian Albrechts University Kiel, Olshausenstr. 40, Kiel, 24098, Germany

    Peer Wulff

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  1. Andrew J. Murray
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  2. Peer Wulff
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Correspondence to Andrew J. Murray or Peer Wulff .

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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Benjamin R. Arenkiel

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Murray, A.J., Wulff, P. (2015). Remote Control of Neural Activity Using Chemical Genetics. In: Arenkiel, B. (eds) Neural Tracing Methods. Neuromethods, vol 92. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1963-5_8

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  • DOI: https://doi.org/10.1007/978-1-4939-1963-5_8

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  • Publisher Name: Humana Press, New York, NY

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