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Epigenetics of Gastric Cancer

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Cancer Epigenetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1238))

Abstract

Epigenetic changes frequently occur in human gastric cancer. Gene promoter region hypermethylation, genomic global hypomethylation, histone modifications, and alterations of noncoding RNAs are major epigenetic changes in gastric cancer. As a key risk factor of gastric cancer, H. pylori infection is an independent predictive indicator of gene methylation. A growing number of epigenetic studies in gastric cancer have provided lots of potential diagnostic and prognostic markers and therapeutic targets.

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Abbreviations

5-aza-CR:

5-azacytidine

5-aza-CdR:

5-aza-2′-deoxycytidine

GC:

Gastric cancer

HATs:

Histone acetyltransferases

HDACs:

Histone deacetylases

HDMs:

Histone demethylases

HMTs:

Histone methyltransferases

LncRNA:

Long noncoding RNA

TSA:

Trichostatin A

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China

    Mingzhou Guo & Wenji Yan

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  1. Mingzhou Guo
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  2. Wenji Yan
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Correspondence to Mingzhou Guo .

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Editors and Affiliations

  1. National Institutes of Health, Rockville, Maryland, USA

    Mukesh Verma

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Guo, M., Yan, W. (2015). Epigenetics of Gastric Cancer. In: Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 1238. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1804-1_41

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  • DOI: https://doi.org/10.1007/978-1-4939-1804-1_41

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1803-4

  • Online ISBN: 978-1-4939-1804-1

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