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Comparative Analysis of Gene Expression: Uncovering Expression Conservation and Divergence Between Salmonella enterica Serovar Typhimurium Strains LT2 and 14028S

  • Paolo Sonego
  • Pieter Meysman
  • Marco Moretto
  • Roberto Viola
  • Kris Laukens
  • Duccio Cavalieri
  • Kristof EngelenEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1231)

Abstract

Different strains of the same organism can share a large amount of their genetic material, the so called core pangenome. Nevertheless, these species can display different lifestyles and it is still not well known to what extent the core pangenome plays a role in the divergence of lifestyles between the two organisms. Here, we present a procedure for uncovering the conservation and divergence of gene expression by using large expression compendia. We will use data from two Salmonella enterica serovar Typhimurium strains as an example here, strain LT2 and strain 14028S, to assess if there are orthologous gene pairs with different expression domains related in both strains.

Key words

Gene expression Expression divergence Expression conservation Salmonella 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Paolo Sonego
    • 1
  • Pieter Meysman
    • 2
    • 3
  • Marco Moretto
    • 1
  • Roberto Viola
    • 1
  • Kris Laukens
    • 2
    • 3
  • Duccio Cavalieri
    • 1
  • Kristof Engelen
    • 1
    Email author
  1. 1.Department of Computational BiologyFondazione Edmund MachSan Michele all’Adige, TrentoItaly
  2. 2.Department of Mathematics and Computer ScienceUniversity of AntwerpAntwerpBelgium
  3. 3.Biomedical Informatics Research Center Antwerp (biomina)University of Antwerp, Antwerp University HospitalEdegem, AntwerpBelgium

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