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Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology

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Book cover RNA Interference

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1218))

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.

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Acknowledgements

This work was supported by grant IGA NT/13547 of the Czech Ministry of Health, by Institutional Resources for Supporting the Research Organization provided by the Czech Ministry of Health in 2012 to Masaryk Memorial Cancer Institute, and by the project “CEITEC–Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068).

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Authors and Affiliations

  1. Central European Institute of Technology, Masaryk University, Kamenice 5, Brno, Czech Republic

    Hana Mlcochova, Renata Hezova & Ondrej Slaby

  2. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, 656 53, Czech Republic

    Hana Mlcochova, Renata Hezova & Ondrej Slaby

  3. Faculty of Medicine, Department of Biology, Masaryk University, Brno, Czech Republic

    Albano C. Meli

  4. INSERM U1046, University of Montpellier I, University of Montpellier II, Montpellier, France

    Albano C. Meli

Authors
  1. Hana Mlcochova
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  2. Renata Hezova
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  3. Albano C. Meli
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  4. Ondrej Slaby
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Corresponding author

Correspondence to Ondrej Slaby .

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Editors and Affiliations

  1. Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway

    Mouldy Sioud

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Mlcochova, H., Hezova, R., Meli, A.C., Slaby, O. (2015). Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology. In: Sioud, M. (eds) RNA Interference. Methods in Molecular Biology, vol 1218. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1538-5_26

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  • DOI: https://doi.org/10.1007/978-1-4939-1538-5_26

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1537-8

  • Online ISBN: 978-1-4939-1538-5

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