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RNA Interference: Mechanisms, Technical Challenges, and Therapeutic Opportunities

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RNA Interference

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1218))

Abstract

The ability to inhibit gene expression via RNA interference (RNAi) has a broad therapeutic potential for various human diseases such as infections and cancers. Recent advances in mechanistic understanding of RNAi have improved the design of functional small interfering (si) RNAs with superior potency and specificity. With respect to delivery, new developments in delivery strategies have facilitated preclinical and clinical siRNA applications. This review provides valuable insights to guide the design and delivery of therapeutic siRNAs.

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Authors and Affiliations

  1. Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310, Oslo, Norway

    Mouldy Sioud

  2. Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Ullernchausseen 70, Montebello, 0310, Oslo, Norway

    Mouldy Sioud

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  1. Mouldy Sioud
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Correspondence to Mouldy Sioud .

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Editors and Affiliations

  1. Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway

    Mouldy Sioud

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Sioud, M. (2015). RNA Interference: Mechanisms, Technical Challenges, and Therapeutic Opportunities. In: Sioud, M. (eds) RNA Interference. Methods in Molecular Biology, vol 1218. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1538-5_1

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  • DOI: https://doi.org/10.1007/978-1-4939-1538-5_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1537-8

  • Online ISBN: 978-1-4939-1538-5

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