Abstract
Autoimmune disease is typically caused by the activated self-reacted immune cells. The mainstream treatment to autoimmune disorders is composed of different mechanisms of immunosuppression. In recent years, a new subtype of T cells called regulatory T (Treg) cells have been identified to maintain the immune homeostasis in terms of suppressing the activated immune components.
According to this discovery, it is suggested that treating autoimmune patients by supplementing Treg cells would be a good choice. However, due to their natural scarcity, it is difficult to isolate a desired number of Treg for this therapeutical approach. Here, we report that by using stem cells, especially the induced pluripotent stem (iPS) cells, we are able to generate a significant amount of Treg cells for the autoimmune prevention and treatment.
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Acknowledgements
This project was funded, in part, under grants with the Grant Number K18CA151798 from the National Institutes of Health and the Barsumian Trust to J.S.
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© 2014 Springer Science+Business Media New York
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Lei, F., Haque, R., Xiong, X., Song, J. (2014). Modulation of Autoimmune Diseases by iPS Cells. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_30
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DOI: https://doi.org/10.1007/978-1-4939-1453-1_30
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-1452-4
Online ISBN: 978-1-4939-1453-1
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